CASCADING EVENTS, TECHNOLOGY AND THE FLOODS DIRECTIVE: FUTURE CHALLENGES


The Hippo pathway terminal effector TAZ/WWTR1 mediates oxaliplatin sensitivity in p53 proficient colon cancer cells

Abstract YAP and TAZ, the Hippo pathway terminal transcriptional activators, are frequently upregulated in cancers.In tumor cells, they have been mainly associated with increased tumorigenesis controlling different aspects from cell cycle regulation, stemness, or resistance to chemotherapies.In fewer cases, they have also been shown to oppose cance

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Lenient rate control versus strict rate control for atrial fibrillation: a protocol for the Danish Atrial Fibrillation (DanAF) randomised clinical trial

Introduction Atrial fibrillation is the most common heart arrhythmia with a prevalence of approximately 2% in the western world.Atrial fibrillation is associated with an increased risk of death and morbidity.In many patients, a rate control strategy is recommended.The optimal heart rate target is disputed despite the results of the the RAte Control

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